FLOATING PULSATILE DRUG DELIVERY SYSTEM THESIS
Braz J Pharm Sci. Gastric pH also has pronounced effect of absorption of drug from delivery system. The particles that retained on sieve no. Size — Dosage form unit with a diameter of more than 7. The results of in vitro buoyancy are shown in Table 2.
Further the tablets are subjected to the following evaluation parameters. Etyan Klausner A et al. The amount of carbon dioxide produced is exclusively proportional to the quantity of sodium bicarbonate in the tablet. A core in cup three component tablet is prepared where in core tablet, an impermeable material surrounding the tablet except the top and soluble hydrophilic polymer layer at the top is designed. Table 1 Formulation composition of ranitidine hydrochloride floating tablets. However, despite Fickian diffusion in the matrix, boundary conditions such as the presence of a stagnant layer or a net charge faced on the release surface may have given origin to a release kinetics characterized by n greater than 0.
The buoyancy is ii In vitro drug release and duration of floating: SA1 achieved maximum swelling of The composition of different formulation of ranitidine hydrochloride floating tablets is shown in Table 1. However, the four times a day dosing regimen often tends to poor patient compliance.
Pulsatile Drug Delivery System Thesis
Intragastric residence positions of systwm and extent by the transit time of food compared with single unit nonfloating units. Oral sustained release gastro-retentive dosage forms GRDFs offer many advantages for drugs with absorption from upper parts of gastrointestinal tract and for those acting locally in the stomach, improving the bioavailability of the medication.
Depending on type short gastric residence time, no risk of dose dumping; reduced risk of release desired.
These cell system and synthetic membrane as well as different types of problems can be overcome with the HBS systems which can dissolution apparatus. Quantification of water uptake studies of SA9 formulation Figure 2. Top cover layer expansion studies of formulation SA9.
Kinetic modelling of drug release The dissolution data of all the formulations were fitted to zero order, first order, Higuchi model and Korsmeyer- Peppas model to study the drug release kinetics. In total 9 formulations are thesus and the tablet with less amount of polymer on top layer achieved less swelling when compared systej tablets having higher concentration of polymer on top layer. Assessing by Vedha hari b. By Scholar Science Journals. This is calculated from the following formula. Gastric pH also has pronounced effect of absorption of drug from delivery system.
The formulation is druf to DSC studies, the melting range is obtained at Statistical Analysis Response surface modeling and statistical analysis are performed using PCP disso V3 software designed by Bharati vidyapeeth Poona college of Pharmacy.
Regression coefficient R values. Propranolol HCl, Ursodeoxycholic acid, Nicardipine.
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Colonic metabolism of ranitidine: Gastroretentive drug delivery system of ranitidine hydrochloride: Aliquots of the samples are collected and analysed for the drug content.
It does not make any Concomitant drug administration— Anticholinergics like difference whether the meal has high protein, fat, or carbohydrate Atropine and Propantheline, Opiates like Codeine and Prokinetic content as long as the caloric content is the same. Table 5 Regression coefficient R 2 values of formulated batches. The present study shows that polymers like HPMC K15MCR and Polyox WSR in combination with sodium bicarbonate as a gas generating agent can be used to develop sustained release floating tablets of ranitidine hydrochloride.
The tablets were prepared by dry granulation method.
The lag time obtained in SA1 is 2. Soppimath KS et al. Drugs that cause irritation and lesion to gastric m u c o s a MP Deliver compositions or release patterns.
After release of drug, the residual system is emptied from the stomach. R values of all the formulation were in the range of 0. Analysis FT-IR measurements of pure drug, polymer and drug- 4. Physiological variables affecting the performance of oral sustained Gastric residence time of a non-disintegrating geometric shape in human floatinv dosage forms.